Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.

Abstract

Chloro- and methyl-substituted 10H-pyrazino[2,3-b][1,4]benzothiazines were prepared and their structures determined by 13C NMR and X-ray crystallographic analysis. Alkylation afforded the 10-[3-(dimethylamino)-1-propyl] derivatives, which were compared to chlorpromazine in receptor-binding assays, in vivo behavioral tests, and electrochemical oxidation… (More)

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@article{Saari1983PreparationOS, title={Preparation of some 10-[3-(dimethylamino)-1-propyl]-10H-pyrazino[2,3-b][1,4] benzothiazines as potential neuroleptics.}, author={W S Saari and Douglas Cochran and Y C Gary Lee and E L Cresson and J. P. Springer and M. Williams and Jessica Totaro and George G Yarbrough}, journal={Journal of medicinal chemistry}, year={1983}, volume={26 4}, pages={564-9} }