Preparation of solid lipid nanoparticles using a membrane contactor.

  title={Preparation of solid lipid nanoparticles using a membrane contactor.},
  author={Catherine Charcosset and Assma Ahmed El-Harati and Hatem Fessi},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  volume={108 1},
Solid lipid nanoparticles (SLN) were introduced at the beginning of the 1990s, as an alternative to solid nanoparticles, emulsions and liposomes in cosmetic and pharmaceutical preparations. The present study investigates a new process for the preparation of SLN using a membrane contactor. The lipid phase is pressed, at a temperature above the melting point of the lipid, through the membrane pores allowing the formation of small droplets. The aqueous phase circulates inside the membrane module… CONTINUE READING

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