Preparation of silymarin proliposome: a new way to increase oral bioavailability of silymarin in beagle dogs.

@article{YanYu2006PreparationOS,
  title={Preparation of silymarin proliposome: a new way to increase oral bioavailability of silymarin in beagle dogs.},
  author={Xiao Yan-Yu and Song Yun-mei and Chen Zhi-peng and Ping Qi-neng},
  journal={International journal of pharmaceutics},
  year={2006},
  volume={319 1-2},
  pages={162-8}
}
The aim of the present study was to find a method to increase oral bioavailability of silymarin, that is to say, by the preparation of silymarin proliposome and to compare the pharmacokinetic characteristics and bioavailability after oral administration of silymarin proliposome and silymarin in beagle dogs. Silymarin proliposome was prepared by the film-deposition on carriers. After the proliposome was contacted with water, the silymarin liposome suspensions formed automatically. The tests of… CONTINUE READING

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