Preparation of photoresponsive DNA tethering ortho-methylated azobenzene as a supra-photoswitch.

Abstract

This unit describes synthetic procedures of photoresponsive DNA via a phosphoramidite monomer composed of D-threoninol as a scaffold and 4-carboxy-2',6'-dimethylazobenzene or 4-carboxy-2'-methylazobenzene that works as a photoswitch more efficiently than previous nonmodified azobenzene (4-phenylazobenzoic acid). With these newly modified-azobenzenes, photoregulatory efficiency of DNA hybridization can be greatly improved. Furthermore, thermal stability of cis-azobenzene of 4-carboxy-2',6'-dimethylazobenzene remarkably increases compared with the previous non-modified azobenzene.

DOI: 10.1002/0471142700.nc0445s46

Cite this paper

@article{Asanuma2011PreparationOP, title={Preparation of photoresponsive DNA tethering ortho-methylated azobenzene as a supra-photoswitch.}, author={Hiroyuki Asanuma and Hidenori Nishioka and Teruchika Ishikawa and Xingguo Liang}, journal={Current protocols in nucleic acid chemistry}, year={2011}, volume={Chapter 4}, pages={Unit 4.45.1-18} }