Preparation of pH-dependent modified-release pellets of urapidil to improve its bioavailability.


OBJECTIVE Modified-release pellets containing urapidil were developed and its in vivo bioavailability was investigated. METHODS Lactose and MCC were used as the main fillers to prepare drug-layer pellets by the powder layering method using centrifugal granulation, and coated in a fluidized bed coater. Pellets with different drug release characteristics… (More)
DOI: 10.3109/10837451003592191


7 Figures and Tables