Preparation of optically active D-arylglycines for use as side chains for semisynthetic penicillins and cephalosporins using immobilized subtilisins in two-phase systems.

@article{Schutt1985PreparationOO,
  title={Preparation of optically active D-arylglycines for use as side chains for semisynthetic penicillins and cephalosporins using immobilized subtilisins in two-phase systems.},
  author={Harold J. Schutt and G Schmidt-Kastner and Andreas Arens and Marianne Prei\ss},
  journal={Biotechnology and bioengineering},
  year={1985},
  volume={27 4},
  pages={420-33}
}
Optically active D-arylglycines, which are of interest for preparation of semisynthetic penicillins and cephalosporins, were isolated from the racemic mixtures of their derivatives using immobilized proteolytic enzyme subtilisin (EC No. 3.4.4. 16). The performance of these reactions in two-phase systems, consisting of water and an immiscible organic solvent, improved the yield, purity, and economics of the process by increasing the substrate solubility and reducing the rate of nonenzymatic… CONTINUE READING