Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluation in vitro and in vivo.

@article{Umeyor2012PreparationON,
  title={Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluation in vitro and in vivo.},
  author={Emmanuel Chukwuebuka Umeyor and Franklin Chimaobi Kenechukwu and John D. N. Ogbonna and Salome Amarachi Chime and Anthony Amaechi Attama},
  journal={Journal of microencapsulation},
  year={2012},
  volume={29 3},
  pages={296-307}
}
OBJECTIVE To formulate and evaluate solid-reversed-micellar-solution (SRMS)-based solid lipid microparticles (SLMs) for intramuscular administration of gentamicin. METHODS SRMS formulated with Phospholipon® 90G and Softisan® 154 were used to prepare gentamicin-loaded SLMs. Characterizations based on size and morphology, stability and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release of gentamicin from the SLMs was performed in phosphate buffer while in vivo release… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 28 references

Development of a binary lipid nanoparticles formulation of itraconzole for parenteral administration and controlled release

  • Kim J-K, Park J-S, Kim C-K
  • Int J Pharm,
  • 2010

British pharmacopoeia: Gentamicin

  • British Pharmacopoeia.
  • Vol. II. London: Pharmaceutical Press, pp. 2751–6…
  • 2009

Preparation and in vitro evaluation of indomethacin loaded solid lipid microparticles

  • MS Eradel, S Gungor, Y Ozsoy, A. Araman
  • Acta Pharma Sci,
  • 2009
2 Excerpts

Evaluation of gum dammar as a novel microencapsulating material for ibuprofen and diltiazem hydrochloride

  • DM Morkhade, SB Joshi
  • Indian J Pharm Sci,
  • 2007
1 Excerpt

Formulation and evaluation of ketorolac tromethamine-loaded albumin microspheres for potential intramuscular administration

  • ST Mathew, SG Devi
  • AAPS PharmSciTech,
  • 2007
1 Excerpt

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