Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluation in vitro and in vivo.

  title={Preparation of novel solid lipid microparticles loaded with gentamicin and its evaluation in vitro and in vivo.},
  author={Emmanuel Chukwuebuka Umeyor and Franklin Chimaobi Kenechukwu and John D. N. Ogbonna and Salome Amarachi Chime and Anthony Amaechi Attama},
  journal={Journal of microencapsulation},
  volume={29 3},
OBJECTIVE To formulate and evaluate solid-reversed-micellar-solution (SRMS)-based solid lipid microparticles (SLMs) for intramuscular administration of gentamicin. METHODS SRMS formulated with Phospholipon® 90G and Softisan® 154 were used to prepare gentamicin-loaded SLMs. Characterizations based on size and morphology, stability and encapsulation efficiency (EE%) were carried out on the SLMs. In vitro release of gentamicin from the SLMs was performed in phosphate buffer while in vivo release… CONTINUE READING


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