Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery.

@article{Xu2009PreparationOM,
  title={Preparation of monodisperse biodegradable polymer microparticles using a microfluidic flow-focusing device for controlled drug delivery.},
  author={Qiaobing Xu and Michinao Hashimoto and Tram T. Dang and Todd Hoare and Daniel S. Kohane and George M Whitesides and Robert Langer and Daniel G Anderson},
  journal={Small},
  year={2009},
  volume={5 13},
  pages={1575-81}
}
Degradable microparticles have broad utility as vehicles for drug delivery and form the basis of several therapies approved by the US Food and Drug Administration. Conventional emulsion-based methods of manufacturing produce particles with a wide range of diameters (and thus kinetics of release) in each batch. This paper describes the fabrication of monodisperse, drug-loaded microparticles from biodegradable polymers using the microfluidic flow-focusing (FF) devices and the drug-delivery… CONTINUE READING

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