Preparation of immune stimulating complexes (ISCOMs) as adjuvants.

  title={Preparation of immune stimulating complexes (ISCOMs) as adjuvants.},
  author={Allan McI Mowat and Geo. Reid},
  journal={Current protocols in immunology},
  volume={Chapter 2},
  pages={Unit 2.11}
Purified proteins are often poorly immunogenic and in such cases the induction of primary immune responses requires use of an adjuvant. The immune stimulating complex (ISCOM) has a unique ability to provoke a full range of immune response to protein antigens, after both parenteral and oral immunization. This unit describes techniques for incorporating proteins into the ISCOM structure, a process that requires the presence of exposed hydrophobic regions on the protein. The basic protocol… CONTINUE READING