Preparation of human tau exon-2- and -10-specific monoclonal antibodies for the recognition of brain tau proteins in various mammals.

@article{Chen2015PreparationOH,
  title={Preparation of human tau exon-2- and -10-specific monoclonal antibodies for the recognition of brain tau proteins in various mammals.},
  author={Cao Chen and Yan Chun Lv and Qi Shi and Bao-yun Zhang and Li-na Chen and Kang Xiao and Jing Sun and Xiao-Ping Dong},
  journal={International journal of molecular medicine},
  year={2015},
  volume={36 2},
  pages={
          455-62
        }
}
The aggregations of tau protein in brain tissue have been described in a large number of neurodegenerative diseases; however, due to the lack of tau isoform- or exon-specific antibodies, the exact situations under which various brain tau isoforms can be found and their exact contributions during disease progression remain unknown. Therefore, in this study, we prepared tau exon-specific monoclonal antibodies (mAbs) that recognize different mammalian tau isoforms. Briefly, 3 Balb/c mice were… CONTINUE READING
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