Preparation of highly dispersible and tumor-accumulative, iron oxide nanoparticles Multi-point anchoring of PEG-b-poly(4-vinylbenzylphosphonate) improves performance significantly.

@article{Ujiie2011PreparationOH,
  title={Preparation of highly dispersible and tumor-accumulative, iron oxide nanoparticles Multi-point anchoring of PEG-b-poly(4-vinylbenzylphosphonate) improves performance significantly.},
  author={Kodai Ujiie and Naoki Kanayama and Kei Asai and Mikio Kishimoto and Yusuke Ohara and Yoshimasa Akashi and Keiichi Yamada and Shinji Hashimoto and Tatsuya Oda and Nobuhiro Ohkohchi and Hideto Yanagihara and Eiji Kita and Masayuki Yamaguchi and Hirofumi Fujii and Yukio Nagasaki},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2011},
  volume={88 2},
  pages={771-8}
}
This paper describes the preparation of iron oxide nanoparticles, surface of which was coated with extremely high immobilization stability and relatively higher density of poly(ethylene glycol) (PEG), which are referred to as PEG protected iron oxide nanoparticles (PEG-PIONs). The PEG-PIONs were obtained through alkali coprecipitation of iron salts in the presence of the PEG-poly(4-vinylbenzylphosphonate) block copolymer (PEG-b-PVBP). In this system, PEG-b-PVBP served as a surface coating that… CONTINUE READING

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