Preparation of extended release solid dispersion formulations of tacrolimus using ethylcellulose and hydroxypropylmethylcellulose by solvent evaporation method.

@article{Tsunashima2016PreparationOE,
  title={Preparation of extended release solid dispersion formulations of tacrolimus using ethylcellulose and hydroxypropylmethylcellulose by solvent evaporation method.},
  author={Daisuke Tsunashima and Kazunari Yamashita and Ken-ichi Ogawara and Kazuhiro Sako and Kazutaka Higaki},
  journal={The Journal of pharmacy and pharmacology},
  year={2016},
  volume={68 3},
  pages={
          316-23
        }
}
  • Daisuke Tsunashima, Kazunari Yamashita, +2 authors Kazutaka Higaki
  • Published in
    The Journal of pharmacy and…
    2016
  • Medicine, Chemistry
  • OBJECTIVES Tacrolimus is a poorly water-soluble compound that is used to prevent allograft rejection. We aimed to prepare an extended release formulation of tacrolimus to achieve both an extended release profile and improved solubility of tacrolimus. METHODS Extended release granules (ERG) of tacrolimus were prepared with lactose, ethylcellulose (EC) and hydroxypropylmethylcellulose (HPMC) via the solvent evaporation method. KEY FINDINGS In an in vitro release study, ERG had an extended… CONTINUE READING

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