Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spray-drying.

@article{Seville2002PreparationOD,
  title={Preparation of dry powder dispersions for non-viral gene delivery by freeze-drying and spray-drying.},
  author={Peter C Seville and Ian W. Kellaway and James C. Birchall},
  journal={The journal of gene medicine},
  year={2002},
  volume={4 4},
  pages={428-37}
}
BACKGROUND Dry powder dispersion devices offer potential for delivering therapeutic macromolecules to the pulmonary epithelia. Previously, freeze-drying (lyophilisation) has been the accepted method for preparing dried formulations of proteins and non-viral gene vectors despite the respirability of such powders being inadequate without further processing. In this study we compare the utility of freeze-drying and spray-drying, a one-step process for producing dry and respirable powders, as… CONTINUE READING

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