Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity.

@article{Sakata2007PreparationO3,
  title={Preparation of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)-5-methoxybenzo[b]furan derivatives and their leukotriene B(4) inhibitory activity.},
  author={Yoko Sakata and Mari Kuramoto and Kumiko Ando and Mami Yamaguchi and Ikuo Kawasaki and Jun-ichi Kunitomo and Takehiko Yokomizo and Yoshitaka Ohishi},
  journal={Organic \& biomolecular chemistry},
  year={2007},
  volume={5 19},
  pages={
          3083-6
        }
}
A series of 3-(4-chlorophenyl)-2-(2-aminothiazol-4-yl)benzo[b]furan derivatives 6-10 were prepared and their leukotriene B(4) inhibitory activity was evaluated. We found that several compounds showed strong inhibition of calcium mobilization in CHO cells overexpressing human BLT(1) and BLT(2) receptors. Among them, 3-(4-chlorophenyl)-2-[5-formyl-2-[(dimethylamino)methyleneamino]thiazol-4-yl]-5-methoxybenzo[b]furan 9b showed the most potent and selective inhibition for the human BLT(2) receptor… 
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6 Citations

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Citation Type

Preparation of leukotriene B(4) inhibitory active 2- and 3-(2-aminothiazol-4-yl)benzo[b]furan derivatives and their growth inhibitory activity on human pancreatic cancer cells.
TLDR
Several compounds showed strong inhibition of calcium mobilization in CHO cells overexpressing human BLT(1) andBLT(2) receptors and growth inhibition to human pancreatic cancer cells MIA PaCa-2.
Structural,Hirshfeld, Spectroscopic, Quantum Chemical and Molecular docking Studies of N'-(4-(4-Chlorophenyl)-1,3-dicyano-5,6,7,8,9,10-hexahydrobenzo[8]annulen 2-yl) N,N-dimethylformimidamide as CCR2 inhibitors
Direct halosulfenylation of benzo[b]furans: a metal-free synthesis of 3-halo-2-thiobenzo[b]furans.
The first example of the direct halosulfenylation of benzo[b]furans with commercially available disulfides and N-halosuccinimides has been achieved, providing an efficient metal-free synthetic…
Chapter 5.3 Five-membered ring systems: Furans and benzofurans
Segregated and alternately stacked donor/acceptor nanodomains in tubular morphology tailored with zinc porphyrin-C60 amphiphilic dyads: clear geometrical effects on photoconduction.
TLDR
The nanotube from dyad 2 with an ester linker consists of a bilayer wall formed with coaxially segregated D and A nanodomains along the tube axis (coaxial D-A heterojunction), thereby displaying explicit photoconductivity with ambipolar carrier transport properties.
A NOVEL ONE-STEP SYNTHESIS OF BENZO〔b〕FURO〔3,2-b〕PYRIDINES HAVING AN AMINO GROUP AT THE 4-POSITION FROM BENZO〔b〕FURO〔3,2-d〕〔1,3〕OXAZINE

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