Preparation of an attenuated dengue 4 (341750 Carib) virus vaccine. II. Safety and immunogenicity in humans.

@article{Hoke1990PreparationOA,
  title={Preparation of an attenuated dengue 4 (341750 Carib) virus vaccine. II. Safety and immunogenicity in humans.},
  author={Charles H. Hoke and Frank J Malinoski and Kenneth H. Eckels and Robert Mcnair Scott and Doria R Dubois and Peter Summers and T E Simms and J M Burrous and S E Hasty and William H. Bancroft},
  journal={The American journal of tropical medicine and hygiene},
  year={1990},
  volume={43 2},
  pages={219-26}
}
To determine safety and immunogenicity, a single 0.5 ml dose of a monovalent live-attenuated dengue (DEN) 4 (341750 Carib) vaccine was given sc to 3 groups of flavivirus nonimmune volunteers in increasing concentrations. Two recipients received 10(3) plaque forming units (PFU)/dose (1:100 dilution of stock vaccine). One remained asymptomatic, but became viremic between days 12 and 15, experienced a mild elevation of temperature (37.4 degrees C), and developed DEN-4 specific antibody. Neither… CONTINUE READING
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…