Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion.

@article{Lu2009PreparationOA,
  title={Preparation of aminoglycoside-loaded chitosan nanoparticles using dextran sulphate as a counterion.},
  author={Enxian Lu and Scott G Franzblau and Hayat Onyuksel and Carmen Popescu},
  journal={Journal of microencapsulation},
  year={2009},
  volume={26 4},
  pages={346-54}
}
PURPOSE To prepare aminoglycoside (AG) (streptomycin, gentamicin and tobramycin) loaded chitosan nanoparticles with high drug incorporation efficiency and test the in vivo oral efficacy of streptomycin (SM) loaded chitosan nanoparticles in a Mycobacterium tuberculosis (TB) chronic infection mouse model. METHOD Dextran sulphate (a polyanion) was used to shield the positive charge of AG and increase the drug incorporation in the chitosan nanoparticle. By varying the concentration of each… CONTINUE READING