Preparation of a-mannoside hydrogel and electrical detection of saccharide-protein interactions using the smart gel-modified gate field effect transistor

Abstract

The purpose of this study was to detect saccharide-protein interaction capitalizing on the gel-modified field effect transistor [FET]. A lectin-sensitive polymer gel that undergoes volume changes in response to the formation of molecular complex between ‘pendant’ carbohydrate and a ‘target’ lectin concanavalin A [Con A] was synthesized. It was revealed that… (More)

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