Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to antiemesis during cancer chemotherapy.

@article{Shimoda2009PreparationOA,
  title={Preparation of a fast dissolving oral thin film containing dexamethasone: a possible application to antiemesis during cancer chemotherapy.},
  author={Hiroyoshi Shimoda and Kazumi Taniguchi and Misao Nishimura and Katsuhiko Matsuura and Tadao Tsukioka and Hirotaka Yamashita and Naoki Inagaki and Kazuyuki Hirano and Mayumi Yamamoto and Y. Kinosada and Yoshinori Itoh},
  journal={European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V},
  year={2009},
  volume={73 3},
  pages={361-5}
}
We prepared fast dissolving oral thin film that contains dexamethasone and base materials, including microcrystalline cellulose, polyethylene glycol, hydroxypropylmethyl cellulose, polysorbate 80 and low-substituted hydroxypropyl cellulose. This preparation showed excellent uniformity and stability, when stored at 40 degrees C and 75% in humidity for up to 24 weeks. The film was disintegrated within 15s after immersion into distilled water. The dissolution test showed that approximately 90% of… CONTINUE READING

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