Preparation of a chiral matrix. Resolution of (6R,S)-N5-formyltetrahydrofolate.

  title={Preparation of a chiral matrix. Resolution of (6R,S)-N5-formyltetrahydrofolate.},
  author={Robert J. Mullin and David S. Duch},
  journal={Journal of chromatography},
  volume={555 1-2},
Combination chemotherapy involving (6R,S)-N5-formyltetrahydrofolate and 5-fluorouracil has raised considerable speculation concerning the effects of the unnatural (6R) diastereomer. The inability to obtain quantities of the individual diastereomers has greatly limited work in this area. Commercially available chiral columns, suitable for diastereomer… CONTINUE READING