Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivites.

@article{Fang2006PreparationOU,
  title={Preparation of UHMWPE particles and establishment of inverted macrophage cell model to investigate wear particles induced bioactivites.},
  author={Hsu-Wei Fang and Yi-Ching Ho and C Yang and Hsuan-Liang Liu and F T Ho and Yung-Chang Lu and Hon-ming Ma and C J Huang},
  journal={Journal of biochemical and biophysical methods},
  year={2006},
  volume={68 3},
  pages={175-87}
}
Total joint replacement surgery has been widely applied to patients with severe osteoarthritis. Aseptic loosening induced by wear particles generated during joint movement is the major reason causing the failure of joint implants. Interaction of ultra-high molecular weight polyethylene (UHMWPE) wear particles with macrophages stimulates the release of inflammatory cytokines and leads to bone resorption and osteolysis. Effect of UHMWPE particle size and shape on the bioactivities remains unclear… CONTINUE READING