Preparation of Thioacid-Containing Amino Acids and Peptides and Their Application in Ligation Reactions

@inproceedings{Rohmer2010PreparationOT,
  title={Preparation of Thioacid-Containing Amino Acids and Peptides and Their Application in Ligation Reactions},
  author={Katja Rohmer and Odin Keiper and Jamsad Mannuthodikayil and Valentin Wittmann},
  year={2010}
}
Introduction Ligation reactions have emerged as an important tool for the chemoselective conjugation of large and complex molecules. One recent example is the reaction of thiocarboxylic acids (thioacids) with electron-deficient organic azides, such as sulfonyl azides [1]. This reaction proceeds at room temperature in different solvents and leads to N… CONTINUE READING