Preparation of Ougodeoxyribonudeoside Raethylphosphonates on a Polystyrene Support

Abstract

An efficient procedure 1s described for synthesizing deoxyribonucleoside methylphosphonates on polystyrene polymer supports which Involves condensing 5 1-dimethoxytrityldeoxynucleoside 3 1-methylphosphonates. The oligomers are removed from the support and the base protecting groups hydrolyzed by treatment with ethylenediamine in ethanol, which avoids… (More)

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