Preparation of Inclusion Complex of Piroxicam with Cyclodextrin by Using Supercritical Carbon Dioxide

Abstract

Forming complexes with cyclodextrins can enhance the dissolution rate, the stability, the solubility and the bioavailability of a drug. In this work, piroxicam/β-cyclodextrin complexes were prepared at solid state by means of supercritical carbon dioxide. The influence of temperature, residence time, water content and a ternary agent, L-lysine, were studied. The complex was characterized by Differential Scanning Calorimetry, Scanning Electronic Microscope and dissolution profile in water. Finally, a complete inclusion was achieved for a piroxicam/β-cyclodextrin/L-lysine mixture by keeping a physical mixture of the three compounds (1:2:1.5 molar ratio) for 2 hours in contact with CO2 at 150°C and 15 MPa.

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Cite this paper

@inproceedings{Sauceau2009PreparationOI, title={Preparation of Inclusion Complex of Piroxicam with Cyclodextrin by Using Supercritical Carbon Dioxide}, author={Martial Sauceau and Elisabeth Rodier and Jacques Fages}, year={2009} }