Preparation of 11C-labelled Raclopride, a new potent dopamine receptor antagonist: preliminary PET studies of cerebral dopamine receptors in the monkey.

@article{Ehrin1985PreparationO1,
  title={Preparation of 11C-labelled Raclopride, a new potent dopamine receptor antagonist: preliminary PET studies of cerebral dopamine receptors in the monkey.},
  author={Erling Ehrin and Lars Farde and Tomas de Paulis and Lars Ove Eriksson and Torgny Greitz and Peter Johnstr{\"o}m and Jan-Eric Litton and J. Lars G. Nilsson and G{\"o}ran Sedvall and Sharon Stone-Elander},
  journal={The International journal of applied radiation and isotopes},
  year={1985},
  volume={36 4},
  pages={269-73}
}
A new dopamine receptor antagonist, Raclopride (S-(-)-3,5-dichloro-N-[(1-ethyl-2-pyrrolidinyl)]methyl-2-hydroxy- 6-methoxybenzamide, FLA 870) (1), has been labelled using [11C]ethyl iodide for alkylation of the nitrogen of the pyrrolidine ring in the corresponding secondary amine (5). The synthesis of 5 and an efficient method for the preparation of [11C]ethyl iodide are described. The 11C-labelled FLA 870 (1) was purified by HPLC and then used in positron emission tomography to visualize the… CONTINUE READING