Preparation of (R)-(−)-mandelic acid and its derivatives from racemates by enantioselective degradation with a newly isolated bacterial strain Alcaligenes sp. ECU0401

@article{He2008PreparationO,
  title={Preparation of (R)-(−)-mandelic acid and its derivatives from racemates by enantioselective degradation with a newly isolated bacterial strain Alcaligenes sp. ECU0401},
  author={Yucai He and Jian-he Xu and Jiang Qiong Pan and Li-ming Ouyang and Yi Xu},
  journal={Bioprocess and Biosystems Engineering},
  year={2008},
  volume={31},
  pages={445-451}
}
An enantioselective mandelate-degrading bacterium, Alcaligenes sp. ECU0401, was newly isolated from soil. By fed-batch culture, (R)-(−)-mandelic acid was successfully prepared in a 5-L fermenter with 32.8% isolated yield and >99.9% enantiomeric excesses (e.e.) from totally 3.04% (w/v) of racemic mandelic acid after 99 h of biotransformation. The optimal reaction pH and temperature were 6.5 and 30 °C, respectively. Using the resting cell as a biocatalyst for asymmetric degradation of racemic… CONTINUE READING
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