Preparation of α-Iodocarbonyl Compounds: An Overall Development

  title={Preparation of $\alpha$-Iodocarbonyl Compounds: An Overall Development},
  author={Rajesh H. Vekariya and Chetan R. Balar and Vinay S. Sharma and Neelam P. Prajapati and Mayur K. Vekariya and Anuj Sharma},
3 Citations
Electrophilic Iodination of Organic Compounds Using Elemental Iodine or Iodides: Recent Advances 2008–2021: Part I
The iodination of organic compounds is of great importance in synthetic organic chemistry. It opens comprehensive approaches for the synthesis of various biologically active compounds. The recent
Visible-Light-Triggered Iodinations Facilitated by Weak Electrostatic Interaction of N-Heterocyclic Carbenes.
By utilizing the electrostatic interaction, the success of a visible-light-triggered radical-radical cross-coupling of N-alkenoxypyridinium salts and NaI is described, giving a variety of α-iodo ketones.


Mild and General Synthesis of Pyrrolo[2,1-a]isoquinolines and Related Polyheterocyclic Frameworks from Pyrrole Precursors Derived from a Mechanochemical Multicomponent Reaction.
The combination of a three-component, solvent-free pyrrole synthesis performed under mechanochemical conditions with a TMSOTf-catalyzed oxonium-mediated cyclization gave general access to
Cu-catalyzed one-pot synthesis of fused oxazepinone derivatives via sp2 C–H and O–H cross-dehydrogenative coupling
An efficient Cu-catalyzed cascade reaction protocol was developed for the synthesis of fused oxazepinone derivatives via sp2 C–H and O–H cross-dehydrogenative coupling. A readily available catalyst,
Direct Annulation of Hydrazides to 1,3,4-Oxadiazoles via Oxidative C(CO)-C(Methyl) Bond Cleavage of Methyl Ketones.
A new strategy for the synthesis of 1,3,4-oxadiazoles was established through direct annulation of hydrazides with methyl ketones. It was found that the use of K2CO3 as a base achieves an unexpected
I2-catalyzed one-pot synthesis of pyrrolo[1,2-a]quinoxaline and imidazo[1,5-a]quinoxaline derivatives via sp3 and sp2 C–H cross-dehydrogenative coupling
An efficient I2-catalyzed cascade coupling protocol was developed for the synthesis of pyrrolo[ 1,2-a]quinoxaline and imidazo[1,5-a], via sp3 and sp2 C–H cross-dehydrogenative coupling, which obtained in good-to-excellent yields with a broad substrate scope.
I2/Cu-mediated self-sorting domino reaction of aryl β-ketoesters into symmetrical 2-carboalkoxy-1,4-enediones: application to synthesis of pyrazine, β-carboline and quinoxalines
A self-sorting domino reaction of aryl β-ketoesters into symmetrical 1,4-enediones is reported by an I2/Cu system. The reaction proceeds through tandem iodination, self-dimerization and Krapcho
Synthesis of α-iodoketals from methyl ketones via sustainable and orthogonal tandem catalysis.
A highly efficient method for the direct synthesis of α-iodoketals from methyl ketones has been developed via sustainable integration of orthogonal tandem catalytic reactions: copper(II) oxide
Water as an Eco-friendly Solvent for Iodination Reactions of Aromatic and Heteroaromatic Compounds
In this review article we have gathered relatively recent publications involving modern methodologies for iodi- nation reactions of aromatic and heteroaromatic compounds using pure water or mixtures
A Useful and Convenient Synthetic Protocol for Iodination of Organic Substrates Using a Combination of Vanadyl Acetylacetonate, Hydrogen Peroxide, and Sodium Iodide
A wide variety of organic substrates can be iodinated selectively in good yields by employing a combination of vanadyl acetylacetonate, hydrogen peroxide, and sodium iodide at ice-bath temperature....
Brønsted Acidic Ionic Liquid Accelerated Halogenation of Organic Compounds with N-Halosuccinimides (NXS)
The reactivity trend and the observed chemo- and regioselectiivities point to an ET process in these IL-promoted halofunctionalization reactions.