Preparation of [76Br]FLB 457 and [76Br]FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET.

@article{Loch1996PreparationO,
  title={Preparation of [76Br]FLB 457 and [76Br]FLB 463 for examination of striatal and extrastriatal dopamine D-2 receptors with PET.},
  author={Christian Loc'h and Christer Halldin and Michel Bottlaender and C G Swahn and Rosa Maria Moresco and Mariannick Mazi{\'e}re and Lars Farde and Bernard Mazi{\`e}re},
  journal={Nuclear medicine and biology},
  year={1996},
  volume={23 6},
  pages={813-9}
}
Both FLB 457 and FLB 463, two substituted benzamides with high affinity for the dopamine D-2 receptors, were labeled with bromine-76 for PET investigations. [76Br]FLB 457 was prepared by electrophilic substitution of the tributyltin precursor. The radiochemical yield was 80%. [76Br]FLB 463 was prepared by a direct electrophilic substitution enhanced by the hydroxyl group of the debromo analogue, with a total radiochemical yield of 50%. Radiochemical and chemical purity values of the… CONTINUE READING
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