Preparation and use of calcium phosphate adsorbed vaccines.

  title={Preparation and use of calcium phosphate adsorbed vaccines.},
  author={E. H. Relyveld},
  journal={Developments in biological standardization},
  • E. H. Relyveld
  • Published 1986 in Developments in biological standardization
Simple or combined D,T,P and inactivated polio vaccines adsorbed onto calcium phosphate are prepared according to two procedures. Antigens can be dialysed in a sodium phosphate solution and quickly mixed with an equal volume of an equimolar solution of calcium chloride, the pH is adjusted to 6.8-7. Toxoids added to the phosphate solution are in this way entrapped within the 3-dimensional network during the formation of the precipitate. Antigens can also be added to a calcium phosphate gel… CONTINUE READING
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