Preparation and stabilization of heparin/gelatin complex coacervate microcapsules.

  title={Preparation and stabilization of heparin/gelatin complex coacervate microcapsules.},
  author={M. Jamie Tsung and Diane J. Burgess},
  journal={Journal of pharmaceutical sciences},
  volume={86 5},
The aims of this study are to optimize conditions for the preparation, stabilization, and harvesting of heparin/gelatin microcapsules prepared by complex coacervation. Microelectrophoresis and dry coacervate weight were used to determine the optimum conditions of pH and ionic strength for maximum heparin/gelatin coacervate yield. Heparin/gelatin microcapsules were formed by complex coacervation in the presence and absence of poly(1-vinyl-2-pyrrolidone) (PVP), which was used as a stabilizer. The… CONTINUE READING