Preparation and stability of N-terminal mono-PEGylated recombinant human endostatin.

@article{Nie2006PreparationAS,
  title={Preparation and stability of N-terminal mono-PEGylated recombinant human endostatin.},
  author={Yongjun Nie and Xin Zhang and Xinchang Wang and Junhui Chen},
  journal={Bioconjugate chemistry},
  year={2006},
  volume={17 4},
  pages={
          995-9
        }
}
Endostatin can specifically inhibit endothelial proliferation and potently inhibit angiogenesis and tumor growth. N-Terminal site-specific mono-PEGylation of recombinant human endostatin (mPEG-rhES) was accomplished by using methoxy poly-ethylene glycol (mPEG) propionaldehyde with an average molecular weight of 5000 Da through a reactive terminal aldehyde group. The site-specific mPEG conjugation was conducted under optimal conditions, which were identified through a statistical L(9)(3(4… CONTINUE READING

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