Preparation and purification of cationic solid lipid nanospheres--effects on particle size, physical stability and cell toxicity.

@article{Heydenreich2003PreparationAP,
  title={Preparation and purification of cationic solid lipid nanospheres--effects on particle size, physical stability and cell toxicity.},
  author={Annette Vinther Heydenreich and Regina Westmeier and Nina Marie Pedersen and Hans Skovgaard Poulsen and Henning Gjelstrup Kristensen},
  journal={International journal of pharmaceutics},
  year={2003},
  volume={254 1},
  pages={
          83-7
        }
}
Cationic solid lipid nanospheres (SLN) were prepared by the microemulsion technique with polysorbate 80 (Tween 80) and butanol as surfactants. The SLN (diameter 100-500 nm, zetapotential around +15 mV) consisted mainly of stearylamine (SA) and different triglycerides. Three different purification methods, ultrafiltration, ultracentrifugation and dialysis, were investigated and compared with the cellular toxicity and physical stability of the dispersions. The cell toxicity was dependent on both… CONTINUE READING
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