Preparation and properties of the methyl ester of $$Willardine^{B_{3 0} }$$ -(human insulin)

Abstract

To study the molecular mechanisms of the interaction of human insulin with the receptors, it is necessary to have available structural analogs of this hormone that retain a high biological activity and are readily detectable in complex mixtures by methods of nondestructive analysis. One such method is spectrometry in the near ultraviolet region. However, human insulin and related animal insulins possess extremely limited UV absorption because of the presence in the A and B chains of insulin of residues of the aromatic protein amino acids tyrosine and phenylalanine, which are relatively weak chromophores.

DOI: 10.1007/BF00714940

Cite this paper

@article{Shvachkin2004PreparationAP, title={Preparation and properties of the methyl ester of \$\$Willardine^\{B_\{3 0\} \}\$\$ -(human insulin)}, author={Yu. P. Shvachkin and Anatoly Nikitina and S. M. Funtova and S. P. Krasnoshchekova and N. A. Voskova and O. N. Ryabtseva and Valerii P. Fedotov and Alexandra I Ivanova}, journal={Chemistry of Natural Compounds}, year={2004}, volume={21}, pages={268-269} }