Preparation and properties of antigen 60 from Mycobacterium bovis BCG.

  title={Preparation and properties of antigen 60 from Mycobacterium bovis BCG.},
  author={Carlo G. Cocito and F. Vanlinden},
  journal={Clinical and experimental immunology},
  volume={66 2},
Antigen 60 (A60) is the main thermostable immunogen of both 'old tuberculin' (OT) and 'purified protein derivative' (PPD), known reagents for cutaneous tests in tuberculosis. It is recognized by bidimensional immunoelectrophoresis with anti-BCG antiserum, where it appears as the less mobile component. A60 was prepared from the cytoplasm of Mycobacterium bovis BCG, and purified by exclusion gel chromatography and lectin affinity chromatography. Labelled A60 was obtained by radioiodination and… CONTINUE READING


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