Preparation and pharmaceutical evaluation for clinical application of high specific activity S-(−)[11C]CGP-12177, a radioligand for &bgr;-adrenoreceptors

  title={Preparation and pharmaceutical evaluation for clinical application of high specific activity S-(−)[11C]CGP-12177, a radioligand for \&bgr;-adrenoreceptors},
  author={K. Nishijima and Y. Kuge and K. Seki and K. Ohkura and K. Morita and K. Nakada and N. Tamaki},
  journal={Nuclear Medicine Communications},
BackgroundAlthough S-(−)[11C]CGP-12177 is a useful positron emission tomography (PET) ligand for &bgr;-adrenoreceptors, the difficulty in radiolabelling the compound has prevented its extensive clinical application. Recently, we have developed a simple synthesis method for S-(−)[11C]CGP-12177. In the present study, we attempted to prepare S-(−)[11C]CGP-12177 with a high specific activity for intravenous injection which is feasible for the clinical evaluation of &bgr;-adrenoreceptors. MethodsThe… Expand
In vitro and in vivo characterization of high specific activity S-(−)[11C]CGP-12177, a radioligand for β-adrenoreceptor, in rats
Abstract Background: S-(−)[11C]CGP-12177 is reported to be a useful PET ligand for β-adrenoreceptor in the heart and lung. Its pharmacokinetic properties, however, have not been fully examined due toExpand
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