Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation.

@article{Lu2012PreparationAI,
  title={Preparation and in vitro evaluation of a folate-linked liposomal curcumin formulation.},
  author={Yao Lu and Nan Ding and Chang Chung Yang and Lei Huang and Jian Liu and Guangya Xiang},
  journal={Journal of liposome research},
  year={2012},
  volume={22 2},
  pages={110-9}
}
Curcumin (CUR), a plant-derived compound, exhibits versatile antitumor effects. However, its poor hydrophilic property limits its application. To circumvent these drawbacks, we encapsulated CUR in liposomes modified with folic acid for better solubility and enhanced tumor targeting. This novel formulation was prepared by a film-dispersion method and characterized by size, zeta potential, drug-loading efficiency, and physical-condition stability. In vitro, cellular uptake efficiency… CONTINUE READING
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