Preparation and in vitro Characterization of Porous Carrier–Based Glipizide Floating Microspheres for Gastric Delivery

@inproceedings{Pandya2011PreparationAI,
  title={Preparation and in vitro Characterization of Porous Carrier–Based Glipizide Floating Microspheres for Gastric Delivery},
  author={Natasha Pandya and Manisha Pandya and V H Bhaskar},
  booktitle={Journal of young pharmacists : JYP},
  year={2011}
}
Floating microspheres have been utilized to obtain prolonged and uniform release of drug in the stomach for development of once-daily formulations. A controlled-release system designed to increase residence time in the stomach without contact with the mucosa was achieved through the preparation of floating microspheres by the emulsion solvent diffusion technique, using (i) calcium silicate (CS) as porous carrier; (ii) glipizide, an oral hypoglycemic agent; and (iii) Eudragit(®) S as polymer… CONTINUE READING
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