Preparation and in vitro/in vivo evaluation of dextran matrix tablets of budesonide in experimental ulcerative colitis in rats.

@article{Ahmadi2011PreparationAI,
  title={Preparation and in vitro/in vivo evaluation of dextran matrix tablets of budesonide in experimental ulcerative colitis in rats.},
  author={Fatemeh Ahmadi and Jaleh Varshosaz and Jaber Emami and Naser Tavakoli and Mohsen Minaiyan and Parvin Mahzouni and Farid Abedin Dorkoosh},
  journal={Drug delivery},
  year={2011},
  volume={18 2},
  pages={122-30}
}
Budesonide is an anti-inflammatory drug of choice for treatment of ulcerative colitis which affects the rectum and a part of or the entire colon. Delivery of budesonide specifically to the colon would increase the efficacy of the drug and reduce the side-effects. The aim of this study was to develop an oral matrix system formulation for budesonide to deliver the major part of the drug to the colon for treatment of ulcerative colitis that has not been reported before. Directly compressed matrix… CONTINUE READING

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