Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates.

@article{Ragupathi2006PreparationAE,
  title={Preparation and evaluation of unimolecular pentavalent and hexavalent antigenic constructs targeting prostate and breast cancer: a synthetic route to anticancer vaccine candidates.},
  author={Govindaswami Ragupathi and Fusataka Koide and Philip O. Livingston and Young Shin Cho and Atsushi Endo and Qian Wan and Maria K Spassova and Stacy J Keding and Jennifer Allen and Ouathek Ouerfelli and Rebecca M. Wilson and Samuel J Danishefsky},
  journal={Journal of the American Chemical Society},
  year={2006},
  volume={128 8},
  pages={2715-25}
}
Several novel, fully synthetic, carbohydrate-based antitumor vaccines have been assembled. Each construct consists of multiple cancer-related antigens displayed on a single polypeptide backbone. Recent advances in synthetic methodology have allowed for the incorporation of a complex oligosaccharide terminating in a sialic acid residue (i.e., GM2) as one of the carbohydrate antigens. Details of the vaccine synthesis as well as the results of preliminary immunological investigations are described… CONTINUE READING

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