Preparation and evaluation of three mucoadhesive dosage forms using (99m)Tc-Ofloxacin.

Abstract

Preparation of three mucoadhesive formulations was optimized and pharmaceutically evaluated. Ofloxacin was radiolabeled with (99m)Tc and radiolabeled complex was characterized by HPLC. (99m)Tc-Ofloxacin was added as a tracer to the formulations namely Oflox C934, Oflox C940 and Oflox HPMC and the formulations were fed orally to rats. Imaging studies were… (More)
DOI: 10.1016/j.apradiso.2014.01.031

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