Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer

@inproceedings{Cai2014PreparationAE,
  title={Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer},
  author={Zheng Cai and Xiaolu Lei and Zhufen Lin and Jie Zhao and Feizhen Wu and Zhaoxiang Yang and Junxue Pu and Zhongqiu Liu},
  booktitle={Acta pharmaceutica Sinica. B},
  year={2014}
}
Borneol is a traditional Chinese medicine that can promote drug absorption from the gastrointestinal tract and distribution to the brain. However, stomach irritation may occur when high doses of borneol are used. In the present work, gastrodin, the main bioactive ingredient of the traditional Chinese drug "Tianma" (Rhizoma Gastrodiae) was used as a model drug to explore reasonable application of borneol. Sustained-release solid dispersions (SRSDs) for co-loading gastrodin and borneol were… CONTINUE READING

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