Preparation and evaluation of solid dispersions of nitrendipine prepared with fine silica particles using the melt-mixing method.

@article{Wang2006PreparationAE,
  title={Preparation and evaluation of solid dispersions of nitrendipine prepared with fine silica particles using the melt-mixing method.},
  author={Liang Wang and Fu de Cui and Hisakazu Sunada},
  journal={Chemical & pharmaceutical bulletin},
  year={2006},
  volume={54 1},
  pages={37-43}
}
Solid dispersions (SD) of nitrendipine (NTD), a poorly water-soluble drug, were prepared using the melt-mixing method with hydrophilic silica particles (Aerosil and Sylysia) with different particle size and specific surface areas as carriers. Powder X-ray diffraction and differential scanning calorimetry evaluation showed that NTD in the SDs treated with the melt-mixing method was dispersed in the amorphous state. FT-IR spectroscopy obtained with the SDs indicated the presence of hydrogen… CONTINUE READING
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