Preparation and evaluation of nanoparticles made of chitosan or N-trimethyl chitosan and a cisplatin-alginate complex.

@article{Cafaggi2007PreparationAE,
  title={Preparation and evaluation of nanoparticles made of chitosan or N-trimethyl chitosan and a cisplatin-alginate complex.},
  author={Sergio Cafaggi and Eleonora Russo and Rossana Stefani and Riccardo Leardi and Gabriele Caviglioli and Brunella Parodi and Gaetano Bignardi and Daniela de Totero and Cinzia Aiello and Maurizio Viale},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2007},
  volume={121 1-2},
  pages={110-23}
}
In this work, nanoparticles with a negative or positive surface charge were prepared through electrostatic interaction of an anionic cisplatin-alginate complex with a cationic polyelectrolyte, namely chitosan or N-trimethyl chitosan (substitution degree of 85%). Statistical experimental design allowed the study of the influence of component amounts on the characteristics of nanoparticles. Mean particle diameter ranged from 180 nm to 350 nm. After 24 h, while the cisplatin-alginate complex… CONTINUE READING