Preparation and evaluation of lactose-modified monoliths for the adsorption and decontamination of plant toxins and lectins.

@article{Kato2011PreparationAE,
  title={Preparation and evaluation of lactose-modified monoliths for the adsorption and decontamination of plant toxins and lectins.},
  author={Haruhito Kato and Hirotaka Uzawa and Takehiro Nagatsuka and Satoshi Kondo and Keita Sato and Isaac Ohsawa and Mieko Kanamori-Kataoka and Yoshiyuki Takei and Shigenori Ota and Masahiro Furuno and Hirofumi Dohi and Yoshihiro Nishida and Y Seto},
  journal={Carbohydrate research},
  year={2011},
  volume={346 13},
  pages={1820-6}
}
A series of sugar-modified porous silica monoliths with different sugar ligands (β-lactoside, β-N-acetyllactosaminide, β-d-galactoside, β-d-N-acetylgalactosaminide and β-d-glucoside) and linkers were prepared and evaluated using plant toxins and lectins including ricin and a Ricinus communis agglutinin (RCA(120)). Among these sugar monoliths, a lactose monolith carrying a triethylene glycol spacer adsorbed ricin and RCA(120) with the highest efficiency. The monolith showed no binding with… CONTINUE READING
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