Preparation and evaluation of diltiazem hydrochloride-gelucire 43/01 floating granules prepared by melt granulation

@article{Shimpi2004PreparationAE,
  title={Preparation and evaluation of diltiazem hydrochloride-gelucire 43/01 floating granules prepared by melt granulation},
  author={Shyam Shimpi and Bhaskar Chauhan and Kakasaheb Ramoo Mahadik and Anant Paradkar},
  journal={AAPS PharmSciTech},
  year={2004},
  volume={5},
  pages={51-56}
}
The basic objective of this study was to explore the application of Gelucire 43/01 for the design of multi-unit floating systems of a highly water-soluble drug diltiazem HCl. Diltiazem HCl-Gelucire 43/01 granules were prepared by melt granulation technique. The granules were evaluated for in vitro and in vivo floating ability, surface topography, and in vitro drug release. Aging effect on storage was vvaluated using scanning electron microscopy, hot stage polarizing microscopy (HSPM… CONTINUE READING
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