Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability.

@article{Ryu2012PreparationAE,
  title={Preparation and evaluation of bicyclol microemulsions for enhanced oral bioavailability.},
  author={Jae Kuk Ryu and Sun Dong Yoo},
  journal={Drug development and industrial pharmacy},
  year={2012},
  volume={38 11},
  pages={1313-8}
}
CONTEXT Bicyclol is a novel anti-hepatitis drug used for the treatment of chronic hepatitis B. Bicyclol is insoluble in water and poorly absorbed after oral administration. To date, formulation development studies to improve the in vitro dissolution profiles of bicyclol and the in vivo oral absorption characteristics have not been performed. OBJECTIVE To overcome problems associated with the poor solubility and low oral bioavailability of bicyclol, a microemulsion system was prepared and… CONTINUE READING