Preparation and enzymatic degradation of monosulfogangliotriaosylceramide.

  title={Preparation and enzymatic degradation of monosulfogangliotriaosylceramide.},
  author={I. Ishizuka and K. Nagai and K. Kawaguchi and K. Tadano-Aritomi and T. Toida and Y. Hirabayashi and Y. Li and S. Li},
  journal={The Journal of biological chemistry},
  volume={260 20},
Gangliotriaosylceramide 3'-sulfate (GgOse3Cer-II3-sulfate) contains the sugar sequence similar to that of GM2 ganglioside except that the NeuAc in GM2 is replaced by a sulfate group. Due to this structural similarity, we have studied the in vitro synthesis of GgOse3Cer-II3-sulfate using the system for GM2. Our results showed that GgOse3Cer-II3-sulfate could be synthesized from lactosylceramide 3'-sulfate and UDP-GalNAc catalyzed by N-acetylgalactosaminyltransferase prepared from rat brain… Expand
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