Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles

@inproceedings{Zhao2014PreparationAE,
  title={Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles},
  author={Kai Zhao and Yang Zhang and Xiaoyan Zhang and Wei Li and Ci Shi and Chen Guo and Chunxiao Dai and Qian Chen and Zheng Jin and Yan Zhao and Hongyu Cui and Yunfeng Wang},
  booktitle={International journal of nanomedicine},
  year={2014}
}
Optimal preparation conditions of Newcastle disease virus (NDV) F gene deoxyribonucleic acid (DNA) vaccine encapsulated in chitosan nanoparticles (pFNDV-CS-NPs) were determined. The pFNDV-CS-NPs were prepared according to a complex coacervation method. The pFNDV-CS-NPs were produced with good morphology, high stability, a mean diameter of 199.5 nm, encapsulation efficiency of 98.37% ± 0.87%, loading capacity of 36.12% ± 0.19%, and a zeta potential of +12.11 mV. The in vitro release assay showed… CONTINUE READING