Preparation and dissolution characteristics of griseofulvin solid dispersions with saccharides.

@article{Saito2002PreparationAD,
  title={Preparation and dissolution characteristics of griseofulvin solid dispersions with saccharides.},
  author={Masataka Saito and Takashi Ugajin and Yasuo Nozawa and Yasuyuki Sadzuka and Atsuo Miyagishima and Takashi Sonobe},
  journal={International journal of pharmaceutics},
  year={2002},
  volume={249 1-2},
  pages={
          71-9
        }
}
To improve the solubility of poorly water-soluble drugs, we studied physical characteristics of griseofulvin (GF) solid dispersions with saccharides as the dispersion carrier using a roll mixing method. In all carriers tested, roll mixtures of GF and saccharides gradually became amorphous, and the solubility of GF increased. The solubility of GF was higher in the mixtures with higher molecular weight carriers such as corn starch and processed starch. The dissolution of GF was markedly improved… CONTINUE READING

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