Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research

@article{Jan2010PreparationAC,
  title={Preparation and characterization of toxic Aβ aggregates for structural and functional studies in Alzheimer's disease research},
  author={Asad Jan and Dean M. Hartley and Hilal A Lashuel},
  journal={Nature Protocols},
  year={2010},
  volume={5},
  pages={1186-1209}
}
The amyloid cascade hypothesis, supported by strong evidence from genetics, pathology and studies using animal models, implicates amyloid-β (Aβ) oligomerization and fibrillogenesis as central causative events in the pathogenesis of Alzheimer's disease (AD). Today, significant efforts in academia, biotechnology and the pharmaceutical industry are devoted to identifying the mechanisms by which the process of Aβ aggregation contributes to neurodegeneration in AD and to the identity of the toxic A… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 58 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 93 references

Similar Papers

Loading similar papers…