Preparation and characterization of specific monoclonal antibodies for the detection of adult worm infections in onchocerciasis.

@article{ChoNgwa2005PreparationAC,
  title={Preparation and characterization of specific monoclonal antibodies for the detection of adult worm infections in onchocerciasis.},
  author={Fidelis Cho-Ngwa and Annika Daggfeldt and Vincent Pryde Kehdinga Titanji and Ko Gr{\"o}nvik},
  journal={Hybridoma},
  year={2005},
  volume={24 6},
  pages={
          283-90
        }
}
Suitable molecular tests for monitoring the viability of adult worms of Onchocerca in vivo are required to accelerate the development of new macrofilaricides in river blindness (onchocerciasis). Hence, three monoclonal antibodies (MAbs) were prepared and evaluated in a sandwich enzyme-linked immunosorbent assay (ELISA) for their abilities to detect circulating adult worm antigens in onchocercal bovine and human sera. The MAbs did not cross-react with a number of control antigens, which included… CONTINUE READING
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